HIP1

Across TCGA pan-cancer cohorts, HIP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HIP1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HIP1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated HIP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, ESCA, and LIHC are the cancer types where HIP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.864	.021	12	view →
ESCA	DFS	Median	II,III,IV	0.178	0.525	.030	9	view →
LIHC	DFS	Median	III,IV	0.046	0.361	<.001	6	view →
COAD	OS	Median	II,III,IV	0.111	0.851	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.560	0.245	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HIP1–UCEC (OS)

Open the UCEC breakdown →