HIP1

Across TCGA pan-cancer cohorts, HIP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HIP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HIP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HIP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where HIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	1.000	0.344	.009	17	view →
LUAD	OS	Quartile	II,III,IV	0.908	0.294	.015	8	view →
CCRCC	DFS	Quartile	III,IV	0.821	0.466	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HIP1–HNSC (OS)

Open the HNSC breakdown →