HIP1

Across TCGA patient cohorts, HIP1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIP1-associated genes across cancer lineages are ATM, eIF4E, and MEK1. Each is linked with HIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HIP1-to-partner and partner-to-HIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HIP1-low versus HIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIP1→partner) and Y-score (partner→HIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.596	-2.662	<.001	<.001	3	3
UCEC	eIF4E →	+0.245	+2.169	.001	.003	3	2
UCEC	MEK1 →	+0.332	+2.321	.015	.005	3	2
UCEC	ASNS →	+0.280	+1.874	.039	.049	3	2
SKCM	Src_pY416 →	+0.366	+3.169	.006	.017	3	2
UCEC	14-3-3_beta →	-0.099	-3.432	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ATM by HIP1 expression — UCEC

Explore this box plot interactively →