HIP1

Across TCGA cell cohorts, HIP1 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HIP1-associated genes across cancer lineages are NLRP8, GZMH, and GZMK. Each is linked with HIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HIP1-to-partner and partner-to-HIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by HIP1-low versus HIP1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIP1→partner) and Y-score (partner→HIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NLRP8 →	+0.023	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GZMH →	+0.036	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GZMK →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	SLC10A2 →	+0.016	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR1L4 →	+0.086	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

NLRP8 by HIP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →