HINT3

Across TCGA pan-cancer cohorts, HINT3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HINT3 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HINT3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HINT3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where HINT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.557	0.869	.009	12	view →
UCEC	DFS	Median	All	0.931	0.782	.018	8	view →
HNSC	OS	Tertile	IV	0.914	0.739	.024	3	view →
PDAC	OS	Quartile	All	0.475	0.294	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HINT3–CCRCC (DFS)

Open the CCRCC breakdown →