HINT3

Across TCGA pan-cancer cohorts, HINT3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HINT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HINT3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HINT3 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where HINT3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HINT3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.472	<.001	11	view →
CCRCC	Female	All	−0.354	<.001	11	view →
LSCC	Female	All	−0.750	<.001	9	view →
LUAD	Female	III,IV	−0.333	<.001	9	view →
COAD	Male	II,III,IV	−0.239	<.001	9	view →
PDAC	Female	All	−0.306	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HINT3–HNSC

Open the HNSC breakdown →