HINT3

Across TCGA patient cohorts, HINT3 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,629 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HINT3-associated proteins across cancer lineages are REPS1, AFDN, and ARFGEF3. Each is linked with HINT3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HINT3-to-partner and partner-to-HINT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HINT3 versus REPS1 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT3→partner) and Y-score (partner→HINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	REPS1 →	+0.280	+0.537	<.001	<.001	3	9
OV	AFDN →	+0.416	+0.368	.002	.008	3	7
OV	ARFGEF3 →	+0.520	+0.554	.003	.003	3	6
BRCA	MAP7 →	+0.650	+0.861	<.001	<.001	3	6
OV	ARID1B →	+0.255	+0.582	<.001	.002	3	5
LUAD	MYO6 →	+0.368	+0.445	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,629 associations by consensus.

HINT3 vs REPS1 — OV

Explore this scatter interactively →