HINT3

Across TCGA patient cohorts, HINT3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,986 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HINT3-associated genes across cancer lineages are SH3BGRL2, UFL1, and SERINC1. Each is linked with HINT3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HINT3-to-partner and partner-to-HINT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HINT3 versus SH3BGRL2 in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT3→partner) and Y-score (partner→HINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL2 →	+0.910	+0.210	<.001	<.001	3	6
BRCA	UFL1 →	+0.662	+0.331	.001	.005	3	5
OV	SERINC1 →	+0.409	+0.364	.008	.008	3	5
LSCC	CAB39L →	+0.671	+0.231	<.001	<.001	3	5
UCEC	C9orf152 →	+1.102	+0.297	.001	.001	3	5
UCEC	ATP6V0A4 →	+1.706	+0.316	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,986 associations by consensus.

HINT3 vs SH3BGRL2 — HNSC

Explore this scatter interactively →