HINT3

Across TCGA patient cohorts, HINT3 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HINT3-associated genes across cancer lineages are eEF2, GAPDH, and MIG-6. Each is linked with HINT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HINT3-to-partner and partner-to-HINT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HINT3-low versus HINT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT3→partner) and Y-score (partner→HINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.498	+3.169	.011	.020	3	1
UCEC	GAPDH →	+0.612	+3.169	.038	.020	3	1
UCEC	MIG-6 →	+0.130	+2.817	.017	.036	3	1
UCEC	ATM →	-0.790	-3.000	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

eEF2 by HINT3 expression — UCEC

Explore this box plot interactively →