HINT3

Across TCGA cell cohorts, HINT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,957 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HINT3-associated GO terms across cancer lineages are 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process, Post-Golgi vesicle-mediated transport, and Golgi to endosome transport. Each is linked with HINT3 in more than 14 cancer types. Because this analysis shows association rather than direction, both HINT3-to-partner and partner-to-HINT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process grouped by HINT3-low versus HINT3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT3→partner) and Y-score (partner→HINT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.108	+0.803	<.001	<.001	3	15
BREAST	Post-Golgi vesicle-mediated transport →	+0.064	+0.588	<.001	<.001	3	12
STOMACH	Golgi to endosome transport →	+0.115	+0.873	.001	.003	3	12
BONE	UDP biosynthetic process →	-0.132	-0.514	.003	.008	3	11
BONE	Pyrimidine ribonucleoside diphosphate biosynthetic process →	-0.132	-0.514	.003	.008	3	11
OVARY	Golgi vesicle transport →	+0.054	+1.053	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,957 associations by consensus.

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process by HINT3 expression — PANCREAS

Explore this box plot interactively →