HINT2

Across TCGA pan-cancer cohorts, HINT2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HINT2 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HINT2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HINT2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where HINT2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.612	0.822	.010	24	view →
CCRCC	DFS	Quartile	All	1.000	0.420	.004	17	view →
UCEC	OS	Tertile	II,III,IV	0.649	1.000	.042	8	view →
LSCC	OS	Median	All	0.920	1.000	.007	6	view →
LUAD	OS	Quartile	All	0.558	0.866	.042	4	view →
PDAC	OS	Quartile	All	0.692	0.328	.006	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HINT2–HNSC (OS)

Open the HNSC breakdown →