HINT2

Across TCGA cell cohorts, HINT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,388 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HINT2-associated GO terms across cancer lineages are Nucleoside triphosphate biosynthetic process, ATP biosynthetic process, and Oxidative phosphorylation. Each is linked with HINT2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HINT2-to-partner and partner-to-HINT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside triphosphate biosynthetic process grouped by HINT2-low versus HINT2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT2→partner) and Y-score (partner→HINT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Nucleoside triphosphate biosynthetic process →	+0.085	+1.022	<.001	.002	3	8
LUNG_NSCLC_LUSC	ATP biosynthetic process →	+0.095	+0.874	.002	.003	3	7
LUNG_NSCLC_LUSC	Oxidative phosphorylation →	+0.088	+0.824	.002	.004	2	8
LUNG_NSCLC_LUSC	Purine nucleoside triphosphate biosynthetic process →	+0.096	+0.889	.002	.002	3	7
LUNG_NSCLC_LUSC	Purine ribonucleoside triphosphate biosynthetic process →	+0.096	+0.889	.002	.002	3	7
LIVER	CMP biosynthetic process →	+0.089	+0.719	.007	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,388 associations by consensus.

Nucleoside triphosphate biosynthetic process by HINT2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →