HINT1P2

Across TCGA pan-cancer cohorts, HINT1P2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HINT1P2 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HINT1P2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HINT1P2 expression acts as an unfavorable survival marker, although some lineages such as LGG and STAD show a favorable association.

BLCA, BRCA, and LGG are the cancer types where HINT1P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.267	0.582	<.001	69	view →
BRCA	OS	Tertile	III,IV	0.653	0.912	<.001	66	view →
LGG	DFS	Median	All	0.898	0.793	<.001	33	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	18	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	18	view →
ESCA	OS	Quartile	II,III,IV	0.333	0.563	.026	17	view →
STAD	DFS	Tertile	IV	0.805	0.213	.033	12	view →
GBM	OS	Tertile	All	0.275	0.477	.019	12	view →
LIHC	OS	Tertile	II,III,IV	1.000	0.416	.039	12	view →
HNSC	DFS	Tertile	All	1.000	0.315	.020	6	view →
KIRP	OS	Tertile	All	0.880	0.951	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HINT1P2–BLCA (DFS)

Open the BLCA breakdown →