HINT1

Across TCGA patient cohorts, HINT1 mutation is significantly associated with the RNA expression of many other genes, with 357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HINT1-associated genes across cancer lineages are MTRNR2L2, DBF4P3, and CWC25. Each is linked with HINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HINT1-to-partner and partner-to-HINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L2 grouped by HINT1-low versus HINT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT1→partner) and Y-score (partner→HINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTRNR2L2 →	+0.542	+2.352	.007	.007	3	1
UCEC	DBF4P3 →	+0.031	+4.075	.006	.007	3	1
UCEC	CWC25 →	+0.520	+3.354	.005	.005	3	1
UCEC	UHRF1 →	+1.086	+3.332	.001	.005	3	1
UCEC	MARCKS →	+1.166	+3.201	<.001	.009	3	1
BLCA	OR51A2 →	+0.089	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 357 associations by consensus.

MTRNR2L2 by HINT1 expression — UCEC

Explore this box plot interactively →