HINT1

Across TCGA patient cohorts, HINT1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HINT1-associated genes across cancer lineages are IRS1, p21, and ASNS. Each is linked with HINT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HINT1-to-partner and partner-to-HINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by HINT1-low versus HINT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT1→partner) and Y-score (partner→HINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.418	+3.000	<.001	.037	3	1
UCEC	p21 →	+0.261	+3.000	.018	.037	3	1
UCEC	ASNS →	+0.614	+3.000	.003	.037	3	1
UCEC	FoxM1 →	+0.444	+3.000	.002	.037	2	1
UCEC	MEK1 →	+0.419	+3.000	.047	.037	2	1
UCEC	PI3K-p85 →	-0.408	-3.000	<.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IRS1 by HINT1 expression — UCEC

Explore this box plot interactively →