HINT1

Across TCGA cell cohorts, HINT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,565 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HINT1-associated GO terms across cancer lineages are Dihydrofolate metabolic process, Ketone metabolic process, and Positive regulation of ligase activity. Each is linked with HINT1 in more than 9 cancer types. Because this analysis shows association rather than direction, both HINT1-to-partner and partner-to-HINT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dihydrofolate metabolic process grouped by HINT1-low versus HINT1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HINT1→partner) and Y-score (partner→HINT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Dihydrofolate metabolic process →	+0.237	+1.405	<.001	<.001	3	10
STOMACH	Ketone metabolic process →	+0.084	+0.655	<.001	.002	3	9
STOMACH	Positive regulation of ligase activity →	+0.138	+0.957	<.001	.004	3	8
LARGE_INTESTINE	Positive regulation of toll-like receptor signaling pathway →	-0.119	-0.439	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of meiotic cell cycle →	+0.080	+0.807	.005	.002	2	8
URINARY_TRACT	Meiotic spindle assembly →	+0.136	+0.739	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,565 associations by consensus.

Dihydrofolate metabolic process by HINT1 expression — URINARY_TRACT

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