HINFP

Across TCGA patient cohorts, HINFP mutation is significantly associated with the RNA expression of many other genes, with 1,634 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HINFP-associated genes across cancer lineages are TYMS, WDR76, and CINP. Each is linked with HINFP in more than 2 cancer types. Because this analysis shows association rather than direction, both HINFP-to-partner and partner-to-HINFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by HINFP-low versus HINFP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINFP→partner) and Y-score (partner→HINFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.839	+3.753	<.001	<.001	3	3
UCEC	WDR76 →	+0.665	+2.091	<.001	.001	3	3
UCEC	CINP →	+0.237	+2.617	.006	.005	3	2
UCEC	CEP76 →	+0.452	+2.470	<.001	<.001	3	2
UCEC	OAZ1 →	+0.527	+3.013	<.001	<.001	3	2
UCEC	TLE6 →	+0.665	+2.091	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,634 associations by consensus.

TYMS by HINFP expression — UCEC

Explore this box plot interactively →