HINFP

Across TCGA cell cohorts, HINFP mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HINFP-associated genes across cancer lineages are DMRTC1, CST4, and OR6B3. Each is linked with HINFP in more than 1 cancer types. Because this analysis shows association rather than direction, both HINFP-to-partner and partner-to-HINFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTC1 grouped by HINFP-low versus HINFP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HINFP→partner) and Y-score (partner→HINFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DMRTC1 →	+0.267	+4.177	<.001	.001	3	2
BLOOD_Lymphoma	CST4 →	+0.652	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	OR6B3 →	+0.030	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR4A47 →	+0.013	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	OR52B2 →	+0.022	+3.714	.001	.006	3	1
BLOOD_Leukemia	SLC32A1 →	+0.725	+4.223	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

DMRTC1 by HINFP expression — BLOOD_Leukemia

Explore this box plot interactively →