HIGD2AP2

Across TCGA pan-cancer cohorts, HIGD2AP2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HIGD2AP2 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HIGD2AP2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HIGD2AP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PCPG show a favorable association.

LUAD, THYM, and PCPG are the cancer types where HIGD2AP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.473	0.104	<.001	70	view →
THYM	DFS	Median	II,III,IV	0.742	0.961	.013	24	view →
PCPG	DFS	Median	All	0.958	0.711	.016	14	view →
KIRP	OS	Median	III,IV	0.788	0.508	.007	11	view →
LIHC	DFS	Quartile	All	0.345	0.467	.020	11	view →
STAD	OS	Median	III,IV	0.537	0.703	.014	10	view →
LAML	DFS	Median	All	0.540	0.252	.026	8	view →
UVM	OS	Median	All	0.939	0.724	.033	7	view →
KIRC	DFS	Quartile	IV	0.267	0.614	.023	6	view →
CESC	OS	Quartile	IV	0.270	0.637	.033	6	view →
READ	OS	Tertile	IV	0.516	0.924	.024	5	view →
OV	DFS	Quartile	II,III,IV	0.333	0.422	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HIGD2AP2–LUAD (DFS)

Open the LUAD breakdown →