HIGD2AP1

Across TCGA patient cohorts, HIGD2AP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,233 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HIGD2AP1-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle phase transition, Negative regulation of mitotic cell cycle, and Organelle inheritance. Each is linked with HIGD2AP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both HIGD2AP1-to-partner and partner-to-HIGD2AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle phase transition grouped by HIGD2AP1-low versus HIGD2AP1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD2AP1→partner) and Y-score (partner→HIGD2AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of mitotic cell cycle phase transition →	+0.062	+0.254	<.001	.003	3	13
STAD	Negative regulation of mitotic cell cycle →	+0.056	+0.251	<.001	<.001	3	13
MESO	Organelle inheritance →	+0.063	+0.143	<.001	.001	3	13
STAD	Regulation of microtubule nucleation →	+0.047	+0.183	<.001	<.001	3	12
ESCA	Mitotic nuclear division →	+0.068	+0.264	<.001	.001	3	12
STAD	Mitochondrial gene expression →	+0.065	+0.266	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,233 associations by consensus.

Positive regulation of mitotic cell cycle phase transition by HIGD2AP1 expression — ESCA

Explore this box plot interactively →