HIGD2A

Across TCGA patient cohorts, HIGD2A protein abundance is significantly associated with the RNA expression of many other genes, with 7,410 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HIGD2A-associated genes across cancer lineages are PMP22, CSF3R, and ANTXR2. Each is linked with HIGD2A in more than 4 cancer types. Because this analysis shows association rather than direction, both HIGD2A-to-partner and partner-to-HIGD2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIGD2A versus PMP22 in OV, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD2A→partner) and Y-score (partner→HIGD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PMP22 →	-1.132	-0.660	<.001	<.001	3	5
COAD	CSF3R →	-1.234	-0.470	<.001	<.001	3	5
OV	ANTXR2 →	-1.196	-0.569	<.001	.001	3	5
OV	FILIP1L →	-1.074	-0.484	<.001	.007	3	5
OV	RASL12 →	-0.958	-0.675	<.001	<.001	3	4
OV	STX2 →	-0.685	-0.469	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,410 associations by consensus.

HIGD2A vs PMP22 — OV

Explore this scatter interactively →