HIGD1B

Across TCGA patient cohorts, HIGD1B protein abundance is significantly associated with the protein abundance of many other proteins, with 924 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HIGD1B-associated proteins across cancer lineages are ACOX1_S26, BCL9L_S1017, and BNIPL_S88. Each is linked with HIGD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD1B-to-partner and partner-to-HIGD1B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIGD1B versus ACOX1_S26 in LSCC, with a Pearson correlation of -0.90.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1B→partner) and Y-score (partner→HIGD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACOX1_S26 →	-2.336	-1.493	.001	<.001	3	1
LSCC	BCL9L_S1017 →	+1.096	+1.359	.001	<.001	3	1
LSCC	BNIPL_S88 →	+1.548	+1.107	.001	<.001	3	1
LSCC	C1orf116_S385 →	+1.446	+1.540	.001	<.001	3	1
LSCC	C1orf116_S496 →	+1.159	+1.080	.002	.001	3	1
LSCC	CALCRL_S411 →	+1.106	+1.566	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 924 associations by consensus.

HIGD1B vs ACOX1_S26 — LSCC

Explore this scatter interactively →