HIGD1B

Across TCGA patient cohorts, HIGD1B mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIGD1B-associated genes across cancer lineages are MIR7702, MIR6864, and RNA5SP411. Each is linked with HIGD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both HIGD1B-to-partner and partner-to-HIGD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7702 grouped by HIGD1B-low versus HIGD1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1B→partner) and Y-score (partner→HIGD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.615	+6.060	<.001	<.001	3	1
UCEC	MIR6864 →	+0.953	+4.061	<.001	.002	3	1
UCEC	RNA5SP411 →	+3.085	+3.393	<.001	.007	3	1
UCEC	RNA5SP412 →	+1.746	+3.967	<.001	.001	3	1
UCEC	MIR7845 →	+1.221	+3.838	<.001	.002	3	1
UCEC	RNA5SP124 →	+0.551	+3.581	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MIR7702 by HIGD1B expression — UCEC

Explore this box plot interactively →