HIGD1B

Across TCGA cell cohorts, HIGD1B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,564 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HIGD1B-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription, elongation, Nuclear export, and Viral translational termination-reinitiation. Each is linked with HIGD1B in more than 10 cancer types. Because this analysis shows association rather than direction, both HIGD1B-to-partner and partner-to-HIGD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription, elongation grouped by HIGD1B-low versus HIGD1B-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIGD1B→partner) and Y-score (partner→HIGD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of DNA-templated transcription, elongation →	+0.076	+0.244	.005	.008	2	11
BREAST	Nuclear export →	+0.057	+0.226	<.001	<.001	3	10
BREAST	Viral translational termination-reinitiation →	+0.085	+0.254	.001	.001	3	10
BREAST	U2-type prespliceosome assembly →	+0.100	+0.205	<.001	.009	2	10
BREAST	Negative regulation of RNA splicing →	+0.088	+0.260	<.001	<.001	3	9
BREAST	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.059	+0.261	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,564 associations by consensus.

Negative regulation of DNA-templated transcription, elongation by HIGD1B expression — PANCREAS

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