HIGD1AP8

Across TCGA pan-cancer cohorts, HIGD1AP8 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated HIGD1AP8 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher HIGD1AP8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1AP8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

MESO, KICH, and SKCM are the cancer types where HIGD1AP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.130	0.546	<.001	66	view →
KICH	DFS	Tertile	All	0.640	1.000	<.001	34	view →
SKCM	OS	Tertile	III,IV	0.653	0.353	.018	30	view →
HNSC	OS	Tertile	All	0.483	0.362	.015	27	view →
ACC	OS	Tertile	II,III,IV	0.747	0.874	.032	27	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
KIRP	DFS	Tertile	II,III,IV	0.518	0.820	.012	12	view →
STAD	DFS	Tertile	IV	0.520	0.250	.033	9	view →
LUAD	DFS	Tertile	III,IV	0.256	0.474	.036	9	view →
BRCA	OS	Tertile	III,IV	0.454	0.577	.046	6	view →
SARC	OS	Tertile	All	1.000	0.831	.031	6	view →
THYM	DFS	Tertile	All	0.659	0.895	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

HIGD1AP8–MESO (DFS)

Open the MESO breakdown →