HIGD1AP6

Across TCGA pan-cancer cohorts, HIGD1AP6 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HIGD1AP6 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher HIGD1AP6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1AP6 expression acts as an unfavorable survival marker, although some lineages such as READ and THYM show a favorable association.

KICH, KIRP, and LIHC are the cancer types where HIGD1AP6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	II,III,IV	0.043	0.950	<.001	78	view →
KIRP	OS	Tertile	III,IV	0.188	0.703	.005	33	view →
LIHC	OS	Tertile	All	0.461	0.707	<.001	27	view →
DLBC	OS	Tertile	All	0.053	0.936	<.001	18	view →
PCPG	DFS	Tertile	All	0.086	0.846	.001	18	view →
LGG	DFS	Tertile	All	0.371	0.735	.003	15	view →
READ	DFS	Quartile	All	0.828	0.298	.025	11	view →
HNSC	DFS	Tertile	III,IV	0.239	0.421	.028	10	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.797	.018	9	view →
SARC	OS	Tertile	All	0.291	0.771	.004	9	view →
ACC	OS	Tertile	III,IV	0.357	0.751	.042	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HIGD1AP6–KICH (DFS)

Open the KICH breakdown →