HIGD1AP4

Across TCGA pan-cancer cohorts, HIGD1AP4 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated HIGD1AP4 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HIGD1AP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1AP4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUAD, UVM, and KIRP are the cancer types where HIGD1AP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.372	0.696	<.001	126	view →
UVM	OS	Tertile	II,III,IV	0.213	0.718	.002	81	view →
KIRP	DFS	Tertile	All	0.625	0.872	<.001	81	view →
KICH	OS	Tertile	II,III,IV	0.070	0.828	<.001	72	view →
KIRC	OS	Tertile	All	0.687	0.822	.015	57	view →
LUSC	OS	Tertile	III,IV	0.411	0.713	.005	57	view →
LGG	OS	Tertile	All	0.570	0.854	<.001	18	view →
BLCA	OS	Tertile	III,IV	0.090	0.582	<.001	18	view →
ESCA	OS	Tertile	All	0.211	0.876	.028	18	view →
STAD	OS	Tertile	IV	0.111	0.433	.002	9	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HIGD1AP4–LUAD (DFS)

Open the LUAD breakdown →