HIGD1AP3

Across TCGA pan-cancer cohorts, HIGD1AP3 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HIGD1AP3 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher HIGD1AP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1AP3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

TGCT, CHOL, and CESC are the cancer types where HIGD1AP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	DFS	Tertile	All	0.049	0.843	<.001	108	view →
CHOL	OS	Tertile	All	0.024	0.675	<.001	90	view →
CESC	OS	Tertile	IV	0.121	0.591	.029	36	view →
LUAD	OS	Tertile	II,III,IV	0.004	0.751	<.001	36	view →
KIRC	DFS	Tertile	All	0.569	0.804	.024	30	view →
PAAD	OS	Tertile	All	0.332	0.596	.034	18	view →
COAD	DFS	Tertile	III,IV	0.189	0.634	.002	18	view →
LIHC	DFS	Tertile	II,III,IV	0.120	0.419	.037	18	view →
BLCA	DFS	Tertile	IV	0.877	0.398	.038	9	view →
READ	DFS	Tertile	III,IV	0.182	0.746	.024	9	view →
BRCA	DFS	Tertile	II,III,IV	0.779	0.892	.041	6	view →
ESCA	OS	Quartile	III,IV	0.601	0.334	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HIGD1AP3–TGCT (DFS)

Open the TGCT breakdown →