Across TCGA pan-cancer cohorts, HIGD1AP13 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HIGD1AP13’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HIGD1AP13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HIGD1AP13 is over-expressed in tumor.
KIRC are the cancer types where HIGD1AP13 tumor–normal differential expression is most reproducible.