HIGD1AP1

Across TCGA pan-cancer cohorts, HIGD1AP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HIGD1AP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HIGD1AP1 RNA is repressed in tumor relative to normal tissue. In most cancer types HIGD1AP1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and STAD are the cancer types where HIGD1AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HIGD1AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.591	<.001	11	view →
COAD	Male	All	−0.630	<.001	9	view →
STAD	Male	All	−0.679	.001	6	view →
UCEC	All	All	+0.423	.013	6	view →
KIRP	All	III,IV	−0.283	.017	4	view →
HNSC	Female	All	−0.240	.015	4	view →
READ	All	All	−0.648	.008	2	view →
KICH	Female	III,IV	+0.710	.032	1	view →
THCA	All	All	−0.140	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HIGD1AP1–KIRC

Open the KIRC breakdown →