HIGD1A

Across TCGA pan-cancer cohorts, HIGD1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HIGD1A data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HIGD1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIGD1A expression acts as an unfavorable survival marker.

COAD, BRCA, and PRAD are the cancer types where HIGD1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.001	0.871	<.001	24	view →
BRCA	OS	Median	All	0.120	0.578	.004	22	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HIGD1A–COAD (OS)

Open the COAD breakdown →