HIGD1A

Across TCGA pan-cancer cohorts, HIGD1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HIGD1A data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher HIGD1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HIGD1A expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

OV, UCEC, and CCRCC are the cancer types where HIGD1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	All	0.426	0.896	.021	20	view →
UCEC	DFS	Tertile	All	0.724	0.945	.004	14	view →
CCRCC	DFS	Tertile	IV	0.105	0.948	.024	12	view →
GBM	DFS	Tertile	All	0.840	0.620	.034	9	view →
HNSC	DFS	Median	All	0.856	0.708	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HIGD1A–OV (DFS)

Open the OV breakdown →