HIF3A

Across TCGA pan-cancer cohorts, HIF3A Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated HIF3A data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HIF3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HIF3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, READ, and CESC are the cancer types where HIF3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.335	0.732	<.001	50	view →
READ	OS	Median	II,III,IV	0.111	0.919	<.001	33	view →
CESC	DFS	Median	II,III,IV	0.144	0.705	.004	18	view →
LUSC	DFS	Median	All	0.214	0.712	.010	15	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
ESCA	OS	Median	III,IV	0.102	0.574	<.001	12	view →
COAD	OS	Median	All	0.527	0.875	.005	12	view →
STAD	OS	Median	All	0.250	0.729	.028	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.962	0.612	.013	6	view →
LGG	OS	Median	All	0.350	0.799	.022	3	view →
SKCM	DFS	Median	All	0.861	0.724	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HIF3A–HNSC (OS)

Open the HNSC breakdown →