HIF1AN

Across TCGA pan-cancer cohorts, HIF1AN mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HIF1AN data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HIF1AN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HIF1AN expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where HIF1AN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.793	0.523	.005	34	view →
PDAC	DFS	Median	III,IV	0.792	0.246	<.001	26	view →
UCEC	OS	Tertile	III,IV	0.309	1.000	.007	20	view →
COAD	DFS	Median	II,III,IV	0.875	1.000	.019	12	view →
LUAD	OS	Quartile	All	0.933	1.000	.007	10	view →
CCRCC	OS	Tertile	All	0.901	1.000	.015	6	view →
LSCC	DFS	Tertile	II,III,IV	0.875	0.676	.025	6	view →
GBM	DFS	Quartile	All	0.449	0.284	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HIF1AN–HNSC (OS)

Open the HNSC breakdown →