HIF1A

Across TCGA pan-cancer cohorts, HIF1A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HIF1A data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HIF1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HIF1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where HIF1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.924	0.444	<.001	23	view →
LUAD	DFS	Tertile	III,IV	0.819	0.333	.001	10	view →
HNSC	DFS	Tertile	III,IV	0.499	1.000	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HIF1A–LSCC (DFS)

Open the LSCC breakdown →