HIF1A

Across TCGA patient cohorts, HIF1A RNA expression is significantly associated with the protein abundance of many other proteins, with 16,952 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HIF1A-associated proteins across cancer lineages are P3H1, P4HA2, and PLAU. Each is linked with HIF1A in more than 6 cancer types. Because this analysis shows association rather than direction, both HIF1A-to-partner and partner-to-HIF1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIF1A versus P3H1 in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1A→partner) and Y-score (partner→HIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P3H1 →	+0.637	+0.678	<.001	<.001	3	7
GBM	P4HA2 →	+0.638	+0.493	.001	.002	3	7
COAD	PLAU →	+0.809	+0.781	.002	.001	3	7
PDAC	CRTAP →	+0.598	+0.531	<.001	<.001	3	7
LSCC	FN1 →	+0.762	+0.567	<.001	<.001	3	7
PDAC	PLOD1 →	+0.610	+0.539	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,952 associations by consensus.

HIF1A vs P3H1 — LSCC

Explore this scatter interactively →