HIF1A

Across TCGA patient cohorts, HIF1A protein abundance is significantly associated with the RNA expression of many other genes, with 8,292 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HIF1A-associated genes across cancer lineages are VEGFA, EGLN3, and HILPDA. Each is linked with HIF1A in more than 3 cancer types. Because this analysis shows association rather than direction, both HIF1A-to-partner and partner-to-HIF1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HIF1A versus VEGFA in GBM, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1A→partner) and Y-score (partner→HIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VEGFA →	+1.637	+0.751	<.001	.001	3	4
LUAD	EGLN3 →	+1.941	+0.801	<.001	<.001	3	4
UCEC	HILPDA →	+1.359	+0.593	<.001	<.001	3	4
UCEC	ADM →	+1.524	+0.545	<.001	<.001	3	4
HNSC	HK2 →	+1.261	+1.085	<.001	.001	3	4
HNSC	BNIP3 →	+0.796	+0.718	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,292 associations by consensus.

HIF1A vs VEGFA — GBM

Explore this scatter interactively →