HIF1A

Across TCGA patient cohorts, HIF1A mutation is significantly associated with the RNA expression of many other genes, with 1,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIF1A-associated genes across cancer lineages are USP9YP2, LINC02399, and OR14A16. Each is linked with HIF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both HIF1A-to-partner and partner-to-HIF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP2 grouped by HIF1A-low versus HIF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1A→partner) and Y-score (partner→HIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP9YP2 →	+0.008	+3.978	<.001	.004	3	3
KIRP	LINC02399 →	+0.097	+5.376	<.001	.005	3	3
BRCA	OR14A16 →	+0.620	+4.064	<.001	.001	3	2
UCEC	POLDIP3 →	+0.344	+2.432	.005	<.001	3	2
UCEC	L3MBTL2 →	+0.256	+2.128	.005	.002	3	2
UCEC	PCMT1 →	+0.386	+2.508	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,870 associations by consensus.

USP9YP2 by HIF1A expression — UCEC

Explore this box plot interactively →