HIF1A

Across TCGA patient cohorts, HIF1A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIF1A-associated genes across cancer lineages are EGFR_pY1068, Bid, and eIF4E. Each is linked with HIF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HIF1A-to-partner and partner-to-HIF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by HIF1A-low versus HIF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1A→partner) and Y-score (partner→HIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.164	-1.459	.044	.012	3	2
UCEC	Bid →	-0.096	-1.459	.013	.012	3	2
UCEC	eIF4E →	+0.160	+2.000	.019	<.001	3	1
UCEC	FoxM1 →	+0.205	+1.594	.014	.021	3	1
UCEC	ACC1 →	+0.255	+1.598	.030	.040	3	1
UCEC	ACVRL1 →	-0.113	-2.102	.010	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by HIF1A expression — UCEC

Explore this box plot interactively →