HIF1A

Across TCGA cell cohorts, HIF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 6,262 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HIF1A-associated GO terms across cancer lineages are Elastin metabolic process, Positive regulation of focal adhesion assembly, and Biological process involved in interaction with host. Each is linked with HIF1A in more than 18 cancer types. Because this analysis shows association rather than direction, both HIF1A-to-partner and partner-to-HIF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Elastin metabolic process grouped by HIF1A-low versus HIF1A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIF1A→partner) and Y-score (partner→HIF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Elastin metabolic process →	+0.330	+1.722	<.001	.001	3	19
BONE	Positive regulation of focal adhesion assembly →	+0.169	+1.437	<.001	<.001	3	14
LIVER	Biological process involved in interaction with host →	+0.148	+1.879	<.001	<.001	3	13
LARGE_INTESTINE	Macroautophagy →	+0.065	+0.949	<.001	<.001	3	13
BONE	Response to acid chemical →	+0.075	+1.781	.001	<.001	3	12
BONE	Regulation of cell-substrate junction organization →	+0.134	+1.609	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,262 associations by consensus.

Elastin metabolic process by HIF1A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →