HID1

Across TCGA patient cohorts, HID1 mutation is significantly associated with the RNA expression of many other genes, with 2,307 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HID1-associated genes across cancer lineages are CRK, RRM2, and DENND10. Each is linked with HID1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HID1-to-partner and partner-to-HID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRK grouped by HID1-low versus HID1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HID1→partner) and Y-score (partner→HID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRK →	+0.302	+1.799	.007	.001	3	4
UCEC	RRM2 →	+0.754	+2.436	<.001	.001	3	4
SKCM	DENND10 →	+0.495	+3.359	.001	.004	3	4
SKCM	KIF11 →	+0.757	+3.469	.004	.002	3	4
UCEC	ACBD5 →	+0.540	+2.058	<.001	<.001	3	4
UCEC	DTL →	+0.697	+2.408	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,307 associations by consensus.

CRK by HID1 expression — UCEC

Explore this box plot interactively →