HID1

Across TCGA cell cohorts, HID1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,513 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HID1-associated GO terms across cancer lineages are Negative regulation of actin nucleation, Negative regulation of Arp2/3 complex-mediated actin nucleation, and Establishment of epithelial cell apical/basal polarity. Each is linked with HID1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HID1-to-partner and partner-to-HID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin nucleation grouped by HID1-low versus HID1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HID1→partner) and Y-score (partner→HID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of actin nucleation →	+0.240	+2.269	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.217	+2.200	.001	<.001	3	14
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.199	-2.180	<.001	<.001	3	14
STOMACH	Glycerophospholipid metabolic process →	+0.049	+2.165	.003	.008	2	15
LUNG_NSCLC_LUAD	Regulation of smooth muscle cell-matrix adhesion →	-0.585	-1.999	.002	<.001	3	11
LUNG_NSCLC_LUSC	Establishment or maintenance of microtubule cytoskeleton polarity →	-0.198	-2.049	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,513 associations by consensus.

Negative regulation of actin nucleation by HID1 expression — LUNG_SCLC

Explore this box plot interactively →