Across TCGA patient cohorts, HIBCH mutation is significantly associated with the RNA expression of many other genes, with 738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIBCH-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RNA5SP422. Each is linked with HIBCH in more than 1 cancer types. Because this analysis shows association rather than direction, both HIBCH-to-partner and partner-to-HIBCH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIBCH→partner) and Y-score (partner→HIBCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.541	+2.933	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.087	+2.071	<.001	.003	3	2
BRCA	RNA5SP422 →	+0.449	+8.055	<.001	.007	3	2
BRCA	RNA5SP416 →	+1.006	+8.471	<.001	.005	3	2
BRCA	RNA5SP423 →	+0.260	+7.731	<.001	.009	3	2
LGG	IGKV1D-32 →	+0.104	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

Exploration

HIBCH survival (RNA) · tumor vs normal (RNA) · all HIBCH data types