Across TCGA patient cohorts, HIBCH mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIBCH-associated genes across cancer lineages are ERK2, MSH2, and MYH11. Each is linked with HIBCH in more than 1 cancer types. Because this analysis shows association rather than direction, both HIBCH-to-partner and partner-to-HIBCH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIBCH→partner) and Y-score (partner→HIBCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.171	+3.000	.049	.036	3	1
UCEC	MSH2 →	-0.221	-2.973	.033	.035	3	1
UCEC	MYH11 →	+1.306	+2.999	.011	.035	3	1
UCEC	p62 Lck ligand →	+0.314	+2.179	.032	.034	3	1
UCEC	RAD51 →	-0.131	-2.000	.037	.032	3	1
UCEC	STAT5a →	+0.509	+3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

HIBCH survival (RNA) · tumor vs normal (RNA) · all HIBCH data types