Across TCGA cell cohorts, HIBCH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,009 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HIBCH-associated GO terms across cancer lineages are Valine metabolic process, L-valine catabolic process, and Branched-chain amino acid catabolic process. Each is linked with HIBCH in more than 16 cancer types. Because this analysis shows association rather than direction, both HIBCH-to-partner and partner-to-HIBCH results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HIBCH→partner) and Y-score (partner→HIBCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Valine metabolic process →	+0.145	+1.053	<.001	<.001	3	17
OVARY	L-valine catabolic process →	+0.145	+1.053	<.001	<.001	3	17
BREAST	Branched-chain amino acid catabolic process →	+0.107	+0.937	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Branched-chain amino acid metabolic process →	+0.115	+1.171	<.001	<.001	3	14
BONE	Mitochondrial tRNA modification →	+0.118	+0.643	.001	.001	3	13
BONE	Mitochondrial tRNA processing →	+0.118	+0.628	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,009 associations by consensus.

Exploration

HIBCH survival (RNA) · tumor vs normal (RNA) · all HIBCH data types