HIBADH

Across TCGA patient cohorts, HIBADH mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HIBADH-associated genes across cancer lineages are Gab2, MEK1, and mTOR_pS2448. Each is linked with HIBADH in more than 1 cancer types. Because this analysis shows association rather than direction, both HIBADH-to-partner and partner-to-HIBADH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by HIBADH-low versus HIBADH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HIBADH→partner) and Y-score (partner→HIBADH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.600	+3.000	.003	.037	3	1
UCEC	MEK1 →	+0.446	+3.000	.034	.037	3	1
UCEC	mTOR_pS2448 →	-0.226	-2.980	.008	.036	3	1
UCEC	VHL →	-1.105	-3.000	.004	.036	3	1
UCEC	C-Raf →	+0.164	+3.000	.047	.037	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.000	.036	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Gab2 by HIBADH expression — UCEC

Explore this box plot interactively →