Across TCGA pan-cancer cohorts, HHLA3-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HHLA3-AS1 data layer.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HHLA3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HHLA3-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and OV show a favorable association.
KIRC, COAD, and LGG are the cancer types where HHLA3-AS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.