HHLA2

Across TCGA patient cohorts, HHLA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,321 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HHLA2-associated proteins across cancer lineages are ASL, DDAH1, and VWA5A. Each is linked with HHLA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HHLA2 versus ASL in LSCC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASL →	+0.420	+0.577	<.001	.006	3	5
LSCC	DDAH1 →	+0.581	+0.616	<.001	<.001	3	4
HNSC	VWA5A →	+0.463	+0.276	<.001	<.001	3	4
LUAD	COBL_S440 →	+0.492	+1.709	.002	.002	3	4
CCRCC	COBL_S917 →	+1.381	+3.227	.001	.004	3	4
LSCC	PLEKHA7 →	+0.467	+0.701	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,321 associations by consensus.

HHLA2 vs ASL — LSCC

Explore this scatter interactively →