HHLA2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HHLA2 protein abundance is significantly associated with the RNA expression of many other genes, with 946 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HHLA2-associated genes across cancer lineages are SAYSD1, MYH15, and TCN2. Each is linked with HHLA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HHLA2 versus SAYSD1 in CCRCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSAYSD1 →+0.457+1.051<.001<.00132
LUADMYH15 →+1.065+1.605<.001<.00132
CCRCCTCN2 →+0.846+0.781<.001<.00132
LUADHNRNPA1P17 →+1.793+1.018<.001<.00132
CCRCCAMACR →+1.208+1.155<.001<.00132
LUADHSCB →-0.508-1.141<.001.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 946 associations by consensus.

HHLA2 vs SAYSD1 — CCRCC

Per-sample scatter of HHLA2 vs SAYSD1 in CCRCC (Pearson r = 0.59).

Explore this scatter interactively →

Exploration