HHLA2

Across TCGA patient cohorts, HHLA2 mutation is significantly associated with the RNA expression of many other genes, with 3,171 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HHLA2-associated genes across cancer lineages are RPL4P6, UBE2MP1, and CHEK1. Each is linked with HHLA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HHLA2-to-partner and partner-to-HHLA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL4P6 grouped by HHLA2-low versus HHLA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HHLA2→partner) and Y-score (partner→HHLA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL4P6 →	+0.297	+2.959	.001	<.001	3	3
SKCM	UBE2MP1 →	+0.316	+2.116	.004	.002	3	2
UCEC	CHEK1 →	+0.534	+1.737	.001	.002	3	2
UCEC	VTI1A →	+0.294	+2.119	.005	.003	3	2
UCEC	BAG3 →	+0.472	+2.321	.003	<.001	3	2
UCEC	AP1S3 →	+0.662	+3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,171 associations by consensus.

RPL4P6 by HHLA2 expression — UCEC

Explore this box plot interactively →